The implication of this question is that the NLL depends on a developed Search and Rescue infrastructure.+1 to the question above. As unsure how Nautilus would work in a less developed location...
It does NOT. It depends on being able to talk to your boat. If your boat has a relatively modern VHF radio on board, it will hear the NLL call if close enough. So, a liveaboard probably is fine. A small 6-passenger day boat, maybe not.