yeah, but where would we be without "it could"? 

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Well . . .to be fair --there is one possible incident that I heard of which might be related to the QC6 female connector supplying an O2 or Dil injector block on an UTD MX Rebreather. Plugging in deco mixes via a QC6 male while underwater might inadvertently inject water as well into the block --and especially if seawater-- the salt crystals could jam-up/clog or seize-open the shrader valve mechanism.
The preventative action is of course to regularly clean & overhaul critical components as part of an annual maintenance schedule. As it applies to a Z-system Distribution Block or IsoFold, simply an ultrasonic bath, clean, dry & inspect. . .
I carry both conventional BP/W and the Z-system sidemount while traveling, because I still elect to keep the long hose paradigm & protocol to be consistent between Backmount & Sidemount. I am confident in my previous & current training to handle the extra "failure points" of both conventional manifolded twinsets as well as the new doubles sidemount Z-system. In Truk Lagoon, I dive backmount 11L doubles & deco bottles on the deeper wrecks 45m & greater in the morning, and use Z-sidemount in the afternoon on the shallower wrecks. Either way, I'm compatible with my Truk Dive Guide who uses DIR/Hogarth long hose configuration with backmount doubles.. . .However, all this banter about "failure" points [of the Distribution Block], detracts from the core and central issue, which is, if you want a system that is consistent with your previous, current or future Hogarthian/DIR/UTD training and skills, that is scalable from single tank to mCCR rebreather, that is capable of mixed team diving, that has interchangeable components and that also allows you to configure and dive a configuration that is best suited for your diving or exploration needs, then the Z-System is the only one that is capable of that.
AG has developed and been using the QC6/block manifold system since 1996 and the first Wakulla push beyond 10k linear feet to 14k, on the big old "fridge" PSCR/Pre-RB80 rebreather: no problems with "failure points" back then . . .and none that I've heard about or experienced at all while using the Z-sidemount system.
If your objective is universality and the ability to muck about solo (or in a "coincidental ad-hoc dive team") in the deepest darkest tightest crawlspaces in some sump, then Z-system is probably not applicable to you. . .And people have been diving side mount with independent cylinders since the 70s and pushed a lot more linear feet of cave. UTD didn't get into side mount until 2010 after two UTD instructors took a course from Bogaerts. That's a fantastic place to get training and I do not doubt anyone's skills. But you're pointing out history.
One of the benefits of side mount is that it puts everything within sight for dealing with issues. The manifold puts it behind my back again. Didn't it just reintroduce the "9 Failures"? Any way Kev, since you like pointing out all the wonderful places you can take your system, I can dive the same places with my regular side mount system. I, however would not take the manifold into the caves that I dive. So, which system is more universal?
A very cursory review of the 9 Failures Heuristic/Problem Solving Model:
For conventional backmount manifolded doubles, the two main objectives are: Determine which side the failure/leak/malfunction is actually occurring, and whether it is due to a post failure or a manifold failure.
The 9 Failures are inductively simplified as follows:
Right Post Failures: Either Fixable (#1) or Non-Fixable (#2).
Right Side Failure in general vicinity of Manifold Crossover to Isolator Knob (#3).
Left Post Failures: Either Fixable (#4) or Non-Fixable (#5)
Left Side Failure in general vicinity of Manifold Crossover to Isolator Knob (#6).
Mistakenly perceiving the Failure on the Right Side, when it's really on the Left (#7).
Mistakenly perceiving the Failure on the Left Side, when it's really on the Right (#8).
Manifold Valve broken/leaking or absolutely have no idea where the Failure is . . .(#9)
--
Similarly for Z-sidemount with the Isofold:
Right Regulator Failures: Either Fixable (#1) or Non-Fixable (#2).
Right Side Failure in general vicinity of Hose connection to Isofold (#3).
Left Regulator Failures: Either Fixable (#4) or Non-Fixable (#5).
Left Side Failure in general vicinity of Hose connection to Isofold (#6).
Right Tank Valve Failure (#7) or Left Tank Valve Failure (#8);
and Z-system gas delivery interruption (#9).
QC6 connection/disconnection scenarios & options are also part of the problem solving outline above for Z-sidemount with Isofold. To recap for Z-Isofold: If you hear bubbles, open both tank valves and isolate; if no bubbles but you have breathing gas interruption -then open both tank valves but do not isolate. In each case go through your 9 Failure heuristics and do final flow checks upon solving the problem. (Also you're supposed to be with teammates as well --ask for their help or long hose donation as needed if the problem cannot be solved).
A very cursory review of the 9 Failures Heuristic/Problem Solving Model:
For conventional backmount manifolded doubles, the two main objectives are: Determine which side the failure/leak/malfunction is actually occurring, and whether it is due to a post failure or a manifold failure.
The 9 Failures are inductively simplified as follows:
Right Post Failures: Either Fixable (#1) or Non-Fixable (#2). (#1) Non Issue or (#2) Non Issue
Right Side Failure in general vicinity of Manifold Crossover to Isolator Knob (#3). (#3) Non Issue
Left Post Failures: Either Fixable (#4) or Non-Fixable (#5) (#4) Non Issue or (#5) Non Issue
Left Side Failure in general vicinity of Manifold Crossover to Isolator Knob (#6).(#6) Non Issue
Mistakenly perceiving the Failure on the Right Side, when it's really on the Left (#7) (#7) Non Issue
Mistakenly perceiving the Failure on the Left Side, when it's really on the Right (#8) (#8) Non Issue
Manifold Valve broken/leaking or absolutely have no idea where the Failure is . . .(#9) (#9) Non Issue
-QC6 connection/disconnection scenarios & options are also part of the problem solving outline above for Z-sidemount with Isofold. To recap for Z-Isofold: If you hear bubbles, open both tank valves and isolate; if no bubbles but you have breathing gas interruption -then open both tank valves but do not isolate. In each case go through your 9 Failure heuristics and do final flow checks upon solving the problem. (Also you're supposed to be with teammates as well --ask for their help or long hose donation as needed if the problem cannot be solved).
And this is also where IMO the UTD Z-system sidemount trumps all: by virtue of that Distribution Block or Isofold/Maniifold, I can access and combine both available remaining tank volumes in a primary long-hose donation to an Out-of-Gas Buddy.Then there is independent side mount:
Or you could just learn how to switch regs like they teach in a PADI OW class and none of this is even an issue