. . .These findings have implications for decompression algorithms. The majority of decompression algorithms model the kinetics of inert gases in a collection of compartments with different time constants spanning the range of tissue kinetics relevant to decompression sickness. Decompression algorithms that accommodate multiple gases may assign different time constants to nitrogen and helium for the same compartment. This structure is appropriate for compartments with slow gas exchange, as evidenced by slower whole-body washout of nitrogen than of helium (3, 14). This slower washout of nitrogen than helium from tissues with slow gas exchange probably underlies the slower required decompression from nitrogen-oxygen than from helium-oxygen saturation dives (15). Saturation dives are hyperbaric exposures of sufficient duration that all body tissues have equilibrated with inspired inert gas partial pressure, and the slowest washout of gas from tissues limits the rate of decompression from such dives.
However, some decompression algorithms assign faster time constants for helium than for nitrogen in all compartments (6). The present findings indicate this latter structure is not appropriate because nitrogen and helium exchange at similar rates in some tissues. For the best of the present models, the slowest compartment time constant for a normal blood flow state was V1/Q = 24 min [Note: Original Ratio Deco used 30min Tissue Compartment Half Time], which is relatively fast in terms of the collection of time constants used in decompression algorithms. The extent of gas uptake into compartments with fast time constants determines the deepest required de- compression stop for dives of insufficient duration for all body tissues to reach equilibration with inspired inert gas partial pressure (bounce dives). A deeper first decompression stop results in longer total decompression time. In model structures with faster helium than nitrogen uptake into fast compartments, a deeper first decompression stop and longer total decompression results from a helium-oxygen bounce dive than from a nitrogen-oxygen bounce dive to the same depth for the same bottom time. This behavior may be inappropriate, but few data exist that directly compare the decompression obligation resulting for helium-oxygen and nitrogen-oxygen bounce dives of identical depth and duration. . .
http://www.physiology.org/doi/pdf/10.1152/japplphysiol.00944.2014