Other people are talking about
DIN plugs, which are just dust caps to keep the din valve clean, and are NOT meant to be in place when the valve is open and there is no side manifold port. If you have a
tight fitting metal DIN plug and the valve is inadvertently opened, you will find it very hard to remove the plug. Not sure why anyone would use these, I thin that it's so you don't accidentally lose gas if the valve opens during transport, but I wouldn't do that. And as has been mentioned upthread, a plastic plug can fail spectacularly in that situation.