From what I understand,
Cologuard has fairly low false negative rates, especially when you consider that Medicare and insurance will pay for it more often than a colonoscopy. "The false positive" rate is debatable because it can find cancer before it is apparent on a colonoscopy. Timing is everything.
Another less expensive option is an annual
FIT (Fecal Immunochemical Test), which some studies show it is as effective as a 5-10 year colonoscopy. Just like Cologuard, a positive test results in a colonoscopy.
There is a lot of competition for Coloscopies as the "gold standard", for obvious reasons.
“This study provides clear data that it’s not as simple as saying, ‘Colonoscopy is the most sensitive test, and therefore it is the best.’ It still prevented cancers.”
www.statnews.com
A seldom mentioned downside of Coloscopies is how it screws up your gut biome, especially in older patients. However, it is a great opportunity to make a conscious effort to rebuild the biome after such an aggressive "cleanse".
My comments should NOT be interpreted as reasons to avoid colon cancer screening! Just a discussion on which strategies to consider.