From ANDI:
[FONT="]Dear Sir,[/FONT]
[FONT="]After a search of the relevant documents here is what we have in the ANDI training materials:[/FONT]
[FONT="]Complete SafeAir User –[/FONT]
2.4-1 CSU CH 2 excerpted from discussion of “early mis-education”.
3. Oxygen toxicity symptoms overlap many Nitrogen narcosis symptoms and were incorrectly diagnosed. Is loss of peripheral vision caused by Nitrogen or Oxygen? Is the “euphoric high” “just” narcosis or are we experiencing the onset of CNS toxicity? Elevated PO2 may actually contribute to narcosis as its lipid solubility is two times that of Nitrogen.1 How can one decipher the real cause of the problem?
Footnote 1 references Meyer-Overton Theory
2.6-2 The primary symptoms of Oxygen toxicity and Nitrogen narcosis have several similarities. Divers breathing gases at partial pressures sufficiently high enough to cause both problems should be extremely cautious and suspect Oxygen as the culprit. This is prudent because it appears that Oxygen is less forgiving than Nitrogen. That is, symptoms may progress without warning. The limits of Oxygen toxicity should not be treated as lightly as many divers treat Nitrogen narcosis.
[FONT="]From the Technical SafeAir Diver text:[/FONT]
2.2-7 There are other inert gases that produce a narcotic effect similar to Nitrogen, but with various degrees of potency. It is believed that the higher the solubility of gas within the fatty tissues, the more potent the effect of the narcosis.1
2.2-8 There has been discussion concerning the relative narcotic effect of SafeAir to Air. [FONT="]ANDI[/FONT] has always stated that “SafeAir will reduce the narcotic effect caused by Nitrogen”. Some have questioned the validity of the “narcosis-reducing capability” of EAN. Only if we extend the Meyer-Overton Theory to include both Oxygen and Carbon Dioxide, may we argue for a “non-narcosis-reducing capability” of EAN. Both Oxygen and Carbon Dioxide are more soluble in fatty tissue than Nitrogen. One could then propose that as the Oxygen concentration increases in a SafeAir mixture, the narcotic effect would increase relative to Air based solely upon the solubility coefficients. It is still uncertain if this is true.
Since our upper limit dosage of Oxygen is 1.46 to 1.6 ata ( [FONT="]ANDI[/FONT]’s Caution Zone ), and until a case study is performed to evaluate Oxygen’s narcotic effect at these dosages, [FONT="]ANDI[/FONT] will not address Oxygen’s possible narcotic effect and continue to state that “SafeAir will reduce the narcotic effect caused by Nitrogen”.2-3
Frankenhaeusser,M; Graff-Lonnevig,V;Hesser,C.M.:Effects of psychomotor functions of different nitrogen-oxygen gas mixtures at increased ambient pressures. Acta Physiol Scand.59:400-409, 1963.
Albano, G; Criscuoli, P.M; Ciulla, C.: La sindrome neuropsichica di profondita. Lav Um 14:351-358, 1962.
Bennett P., Blenkarn GD: Arterial blood gasses in man during inert gas narcosis. Journal Applied Physiology 36:45-48, 1974.
Larrabee MG, Posternak JM: Selective action of anesthetics on synapses and axons in mammalian sympathetic ganglia. Journal Neurophysiology 15:91-114, 1952.
[FONT="]I hope this is assistance.[/FONT]
[FONT="]I can have the ITD Board review these statements for currency as the above was written by Ed Betts about 18 years ago[/FONT]
[FONT="]Best wishes,[/FONT]
[FONT="]ANDI Tech Support[/FONT]
1 Meyer-Overton Theory
1 The Meyer - Overton Theory states that as the solubility in lipid tissue increases, the narcotic potency also increases. This has been demonstrated as true for all of the biochemically inert gasses. EAB.
2 Frankenhaeusser,M; Graff-Lonnevig,V;Hesser,C.M.:Effects of psychomotor functions of different nitrogen-oxygen gas mixtures at increased ambient pressures. Acta Physiol Scand.59:400-409, 1963.
3 Albano, G; Criscuoli, P.M; Ciulla, C.: La sindrome neuropsichica di profondita. Lav Um 14:351-358, 1962.
[FONT="]Dear Sir,[/FONT]
[FONT="]After a search of the relevant documents here is what we have in the ANDI training materials:[/FONT]
[FONT="]Complete SafeAir User –[/FONT]
2.4-1 CSU CH 2 excerpted from discussion of “early mis-education”.
3. Oxygen toxicity symptoms overlap many Nitrogen narcosis symptoms and were incorrectly diagnosed. Is loss of peripheral vision caused by Nitrogen or Oxygen? Is the “euphoric high” “just” narcosis or are we experiencing the onset of CNS toxicity? Elevated PO2 may actually contribute to narcosis as its lipid solubility is two times that of Nitrogen.1 How can one decipher the real cause of the problem?
Footnote 1 references Meyer-Overton Theory
2.6-2 The primary symptoms of Oxygen toxicity and Nitrogen narcosis have several similarities. Divers breathing gases at partial pressures sufficiently high enough to cause both problems should be extremely cautious and suspect Oxygen as the culprit. This is prudent because it appears that Oxygen is less forgiving than Nitrogen. That is, symptoms may progress without warning. The limits of Oxygen toxicity should not be treated as lightly as many divers treat Nitrogen narcosis.
[FONT="]From the Technical SafeAir Diver text:[/FONT]
2.2-7 There are other inert gases that produce a narcotic effect similar to Nitrogen, but with various degrees of potency. It is believed that the higher the solubility of gas within the fatty tissues, the more potent the effect of the narcosis.1
2.2-8 There has been discussion concerning the relative narcotic effect of SafeAir to Air. [FONT="]ANDI[/FONT] has always stated that “SafeAir will reduce the narcotic effect caused by Nitrogen”. Some have questioned the validity of the “narcosis-reducing capability” of EAN. Only if we extend the Meyer-Overton Theory to include both Oxygen and Carbon Dioxide, may we argue for a “non-narcosis-reducing capability” of EAN. Both Oxygen and Carbon Dioxide are more soluble in fatty tissue than Nitrogen. One could then propose that as the Oxygen concentration increases in a SafeAir mixture, the narcotic effect would increase relative to Air based solely upon the solubility coefficients. It is still uncertain if this is true.
Since our upper limit dosage of Oxygen is 1.46 to 1.6 ata ( [FONT="]ANDI[/FONT]’s Caution Zone ), and until a case study is performed to evaluate Oxygen’s narcotic effect at these dosages, [FONT="]ANDI[/FONT] will not address Oxygen’s possible narcotic effect and continue to state that “SafeAir will reduce the narcotic effect caused by Nitrogen”.2-3
Frankenhaeusser,M; Graff-Lonnevig,V;Hesser,C.M.:Effects of psychomotor functions of different nitrogen-oxygen gas mixtures at increased ambient pressures. Acta Physiol Scand.59:400-409, 1963.
Albano, G; Criscuoli, P.M; Ciulla, C.: La sindrome neuropsichica di profondita. Lav Um 14:351-358, 1962.
Bennett P., Blenkarn GD: Arterial blood gasses in man during inert gas narcosis. Journal Applied Physiology 36:45-48, 1974.
Larrabee MG, Posternak JM: Selective action of anesthetics on synapses and axons in mammalian sympathetic ganglia. Journal Neurophysiology 15:91-114, 1952.
[FONT="]I hope this is assistance.[/FONT]
[FONT="]I can have the ITD Board review these statements for currency as the above was written by Ed Betts about 18 years ago[/FONT]
[FONT="]Best wishes,[/FONT]
[FONT="]ANDI Tech Support[/FONT]
1 Meyer-Overton Theory
1 The Meyer - Overton Theory states that as the solubility in lipid tissue increases, the narcotic potency also increases. This has been demonstrated as true for all of the biochemically inert gasses. EAB.
2 Frankenhaeusser,M; Graff-Lonnevig,V;Hesser,C.M.:Effects of psychomotor functions of different nitrogen-oxygen gas mixtures at increased ambient pressures. Acta Physiol Scand.59:400-409, 1963.
3 Albano, G; Criscuoli, P.M; Ciulla, C.: La sindrome neuropsichica di profondita. Lav Um 14:351-358, 1962.