Accidentally diving with a closed isolator valve: diver runs suddenly OOA. Sure it's recoverable by switching the reg, but that's not what comes to your mind as a solution right away if you have no experience with doubles.
The "surprise closed isolator" happened at least once while my wife and I were learning doubles. This happened in the shallows of a lake, though. Knowing that just such a thing could happen, we practiced with the doubles in benign environments for a good long time until we knew how to handle them. Oh, and then we dived from a boat off the coast of North Carolina, and my wife experienced what we figured out afterwards was a right post roll-off when the valve handwheel caught the line between the hang bar and the pitching boat. Another learning experience. Yes, there are things that can happen.