Probably not for that. Personally Iike all standard size ports so I can use standard long hoses. ymmv.
The one thing to consider is the hose routing if you intend to use 2 of them for dual first stages. All of the hoses will need to point downward when the regs are on the tanks. You'll need 2 lp and one hp port on one side of the reg all pointing in roughly the same direction. The offset HP port on the MR22 makes me think that your hose routing will look gibbled. The MR52 looks more suitable for this application to me.
Once again, i'll mention the caveat that I don't use these regs so get advice from people using them as well.
R..
I i turn the regs DFC-ports down, i will have on the primary reg(behind my right shoulder), longhose and drysuite facing down and HP-SPG 45* down to center. and on the secondary reg shorthose/bcd down and the HP-transmitter 45* down-out.
Or switch SPG and transmitter.
I think the only difference (hoserouting-wise) is the angel of the HP ports.
I more thinking that the LP ports are in the same plane- sotosay, so the reg-hose will go down closer to the backplate than the inflator-hose. But thats maybe is not a big issue.