In trying to decide which of my regs I'll use for my upcoming doubles and eventual cave training project, I'd go with 2 MK10s, D300 on the long hose, 109 (old metal unbalanced 2nd stage) on the neckless. I could easily substitute a G250 for either of the 2nds.
My reasoning is that the MK10s are ultra-proven workhorses that are simple and reliable while providing plenty of air. Just to be on the paranoid side, I'd make sure the HP o-ring in each was polyurethane duro 90. The choice of 2nds is a little more subjective, the D300 is just very comfortable and stable and breathes very smoothly while being very resistant to freeflows. The 109 is a very simple and extremely durable reg. Even the unbalanced poppet version breathes better than most "modern" regs, and is dirt cheap to rebuild. Once a reg has 20 years plus of service on it, it's proven its reliability.
Anyhow, that's my current take on it. In an overhead situation, reliability is by far the most important criteria for a reg; they all can be made to breathe very easily.