I think that as a general rule, when you are diving to the extremes of human experience, you need to be very careful and cannot assume that what works well in more normal dives would work well at those extremes.
As an example, go into multi-deco and use any of the algorithms in there to plan a deco dive to 200 feet at an altitude of 16,000 feet. You will get a dive plan. How can anyone know how well that plan will work on a dive at a depth and altitude combination that has never been done successfully by anyone in the world?
I know two people who did attempt a dive at that depth and altitude, and it did not go well. I don't know what their plan was, or how they came up with it. I do know that after it was over, I talked to a dive theorist who works with NASA and the Pentagon on high altitude decompression planning for astronauts and U-2 pilots. He said that as you go to such extremes, factors that do not have to be considered at lower altitudes start to become very important. (He mentioned water vapor volume as an example.) He said he believed there are only about 6 people in the world with the requisite knowledge to plan such a dive, and I know that no one like that was consulted. Just going off the top of his head, he estimated a dive schedule that was nowhere close to what you would get planning that dive with any algorithm in multi-deco.
I would say the same thing would be true about very deep dives. Dives like that have not been done with enough frequency and with enough study for anyone to be confident they are following a plan that will work.