I read somewhere here in SB in an old thread that cordura is especialy hard to make something stick. Even Aquaseal can be peeled off from bare cordura.Depends on whether the inflatable is made from hypalon or PVC. PVC patches last a couple of years, I’ve seen hypalon patches properly applied go for 10.
Wing bladders get patched with aquaseal. I doubt you’d glue a whole new assembly in, I expect you’d remove the old assembly, glue in a strongback around the hole, and insert a flange.
That’s how I’d do it anyway.
Flanges are RF welded, not glued. When cordura breaks, there is little to do. Only cyanoacrylate sticks, but it's not flexible, so it will break aside.
That's why spare flanges need somewhere to anchor and sealant.