Simple things can make for safer journeys.
"McGeyver Specialty Diver"
I don't care if it's Bonaire or Bombay, Paranoid People Prevail.
Lock your room door at night. Use the chain. Balance an upturned beer bottle just behind it. Sometimes I just use a wooden chair- not to "wedge" the door- that's just plain silly. Place it balanced so that anyone opening the door would tip it over. Noisemakers come in all forms, not just electronic sirens!
Windows and balconies are tougher, but only because you have to bring along a spool of carpet/button sewing thread... the heavy duty kind.
Make yourself a trip wire. Knee level, out of the light- tie one end to the wall, the other end to... you guessed it- and upturned wine bottle. Don't forget that high window in the toilet- the one you couldn't crawl through!
Room invaders most often work in pairs- one waits at the final exit portal (not necessarily the initial entrance) to facilitate the fast exit- possibly even to cause a block or physical cessation to your pursuit.
I've travelled all over the world, sometimes overnighted in some dreadful places.
Wall safes and provided room safes? Worst place you could put anything. Either get smart and get clever about secreting cash (not the wallet) within your stowed belongings or somewhere in the room, or speak with hotel management about holding a sealed manilla envelope in your name.
When we travel, we also carry what is called a "drop wallet". If accosted, it makes a handy decoy. Present it, open it, show a few expired credit cards, a few 5 bucks in singles- then toss it at an oblique angle to your new friend- and skeedaddle.
Remember: Cash, Credit Cards and Driver's Licenses are waterproof. If you want to take it diving, by all means, do so.
If that doesn't work, you might want to learn how to use a knife, then stow one in your checked bags. I've only needed once on a dive trip, but we sure changed those sap's minds in Quito- both me and the little Missus displayed sharp shiny opbjects with a snap.
Paranoid? Maybe, but alive. This stuff doesn't cost you much in time or material.