Good to see that you have updated your files on the body's endogenous production of CO.
Here is a good summary on some of the physiological processes for which the signaling molecule is CO. Adding in an external source of CO can severely disrupt those critical physiological systems such as blood pressure or oxygen sensing.
http://pharmrev.aspetjournals.org/content/57/4/585.full.pdf
You should investigate hydrogen sulfide (H2S) too because we make that toxic gas as well.
Actually, it is not possible to be "up to date" on everything, and this old vintage diver has tried to do so in many areas. My main expertise is in industrial hygiene, where I have been investigating hearing loss and the effects of noise on workers. In this area, reactive nitrogen species (such as NO) is a metabolite of high noise levels, and research shows that this happens intra-cellularly. The effects of high noise such as IED explosions can cause hearing loss by destruction of hair cells inside the cochlea days after the event, and
researchers are now looking at using anti-oxidants as a possible prevention after the fact of noise-induced hearing loss. However, my first introduction to human physiology has to do with diving, which I began in 1959. I became a NAUI Instructor (#2710) in 1973, and have published several articles on diving. I do know how to research things, and if I am challenged such as the information you gave me, I tend to respond by saying that it is interesting, but I want to find more before acknowledging the new information.
I have now found an even better reference, one that gives the normal levels of CO, which shows that "The normal endogenous production of carbon monoxide is sufficient to saturate 0.4-0.7% of the body's haemoglobin--that is, 0.4-0.7% carboxyhaemoglobin, at rest, but that a national survey in North America found 1-2% carboxyhaemoglobin in urban nonsmokers as a result of environmental exposure and 5-6% in smokers (cigarette smoke contains about 4% carbon monoxide)..."
Carbon monoxide poisoning
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544692/pdf/bmj00267-0003.pdf
So my contention of environmental CO being a main cause is still valid, although there is some production by the human body. Note that the level of carboxyhaemoglobin is not directly related to the ppm in the exhaled breath, but the reference by swamp diver showed normal healthy people exhaling about 1.8 ppm. There were 13 control subjects in a study, but no reference to whether there was environmental CO--assumed not (
Wu and Wang, page 608).
John
John C. Ratliff, CSP, CIH, MSPH
PS--I like your reference; thanks!