I’m flying from SFO which makes it a bit easier. But it’s SFO to Munich to Cairo. Then you can take a flight to whatever domestic destination you need. Layovers in Munich are about 3-4 hours. It’s a good cushion for international connections and thankfully I have lounge access. If I depart on Friday evening around 7PM from SFO, I would arrive Sunday wee hours at 3AM-ish including the time change. There’s another 3-4 hour layover to connect to a domestic Egypt flight which is also a good cushion for delays and issues. On average, the flight is 50% more expensive than flying to Southeast Asia for me. But I have to do it because I want to check out the Red Sea.
Do check out Egypt topside and then head to Jordan as well.