A high pressure seat failure would be no worse than the first stage freezing open on an ice dive - the flow is more or less unrestricted but the pressure drops significantly as it leaves the valve and the pressure will never be anywhere near 3000 psi past the first stage.HP seat failure would be a bad case scenario; freeflow would be an understatement if the 2nds got a blast of 3000PSI air. Maybe "worst" case would be total loss of flow, but I don't see how that could happen other than a main spring failure, which I've never heard of.
Mainspring failure is a very rare occurrence primarily associated with over shimming a spring, causing it to function outside it's designed working range. Popular opinion is that this would in most cases not result in a loss of flow in a piston reg as the piston is downsteam of the orifice and would float between the open and closed position without spring pressure and would probably freeflow. Given the upstream location of the seat carrier in a diaphragm reg, the odds are higher that a mainspring failure could result in a failure to deliver air.