Put another way some filters you can mount horizontally (but not all) but separators in the main must be mounted vertically.
Again the detail drives the answer. First you need to call the "filters" Chemical dehydrator filter towers.
These generally are two types the first flow up the centre tube into the chemical the second type flow up the outside of the filter crtridge and then down from the top into the chemical cartridge.
The 2nd type are found on pretty much all the cheap compressor designs when the filter tower can also act as a cheap separator like the Bauer Triplex, P21 etc while the more expensive say Bauer P41 P61 would use the first flow option.
For the filter design I produced for the sidewinder the water condensate was removed by the two (2) small separators on the modified SA block. The HP gas then went straight into the first tower but met silica gel (not molecular sieve)
this absorbed any water droplets or condensed water vapour as the gas was still at 100% humidity at this point.
Then it meets Activated Alumina this again is very tolerant of liquid water and does not produce an exothermic reaction as straight molecular sieve would have done, After this Molecular sieve is used to adsorb the remaining water vapour and reduce the dewpoint. Small 15mm thick 7Mu poyester filter pads separated the various chemicals in the pack.