Yeah, I have descended in reasonable conditions on 12/65 a few times with no ill effects (although it was annoying getting slammed in the face with surface chop on one dive as we tried to fix a reg leak)
for 10/70 I would almost certainly just breathe the 190 bottle on descent, not just to have something breathable but to save the bottom gas a little too (depending on how much of the 190 bottle you expect to use of course)
Having experienced the first symptoms of Hypoxia @ 6m on 12/65 I'm very wary of doing that now. It doesn't take much exertion for issues to start, and it's something that can be easily avoided.
Thanks
John