SuPrBuGmAn
Contributor
I always shoot RAW, ISO does impact image quality. I don't know, or care to be honest
, the science behind it - but the results are obvious at full resolution in large steps, not so much in smaller ones.
ISO100 - ISO200 is noticable on my PnS, ISO400 is very noticable.
ISO 100 won't show noticable degradation in image quality until ISO400 with reasonably sized images, even then, its more than workable/saleable from my E500 or E1. ISO800 and even ISO1600 can be cleaned up fairly well if exposed correctly with noise reduction software. DSLRs are much more capable of handling noise than PnSs.

ISO100 - ISO200 is noticable on my PnS, ISO400 is very noticable.
ISO 100 won't show noticable degradation in image quality until ISO400 with reasonably sized images, even then, its more than workable/saleable from my E500 or E1. ISO800 and even ISO1600 can be cleaned up fairly well if exposed correctly with noise reduction software. DSLRs are much more capable of handling noise than PnSs.