I am one who believes the analysis of dive accidents is a great help to the community.
As for manifolds, I have never heard of a closed manifold problem among the people with whom I have dived, but I do have a story that might be telling if I could only figure out what it was telling.
Years ago, when I was finishing my trimix training, I took the final exam. The instructor downloaded the exam in MS Word format from the agency website. IIRC, the exam was about 10 years old. One question had me baffled. I don't remember the exact wording, but it set up a scenario in which a diver is in a dive that seems to be going normally, but when he checks his SPG, he sees that he is going through his gas about twice as fast as expected. I was supposed to suggest a reason.
My instructor explained that the correct answer was that the isolator was closed, so all the gas was coming out of one cylinder. I pointed out that in a normal gear configuration, if the manifold was closed, the diver would not see that I was going through gas too quickly, the diver I would see that he was not going through gas at all. The SPG usually comes off the left post, and the diver usually breathes off the right post. The question would only make sense of the diver had made the highly unusual decision to run the SPG off the right post. My instructor, quite surprised, admitted that I was right and he had never thought of that before. Evidently, neither had any of his students.
So for at least 10 years, people from that agency had been taking that exam. If anyone in that entire agency had noticed this, they either had not notified the agency or the agency had not felt like taking the 5 minutes it would have required to change the MS Word exam and post the new version to the website.
So let's say that in real life a diver with an isolation manifold suddenly has an OOA response during an inhale because of a closed isolator. That means that the diver had not yet checked the SPG at any point in the dive.