GTR in my opinion is a pointless feature, and one that could cause the inexperienced diver to be lulled into a false sense of security. GTR is normally calculated using your current consumption rate. All well and good, but if you use it to push the limits of the dive and then get a situation where you suddenly get elevated consumption, then it's highly possible you'll have got yourself into an OOA situation.
GTR in my opinion is no substitute for gas planning.
I've used it once, when in a difficult situation with a current, and a massively elevated SAC rate, I referred to it while weighing up my options, even then only to double check my mental calcs.
As far as I'm aware all computers with GTR ot TTD (timer to die) as I like to call it, just work on the selected gas. I don't know of any that can take into consideration other gasses and come up with an overall total