It is always reasonable to ask why you want to go deep on any gas. The answer to risk avoidance is stay shallow rather than use Helium. As most of you know, Helium will help reduce risk but is a long way from eliminating it. (Not everyone reading this thread is a trained technical diver)
There is a long history of working dives on air far deeper than modern training agencies like to admit. However most were accomplished using surface supplied systems and divers with literally months (8 hours/day and 5 days/week) of training and many years of experience. Surface supplied doesn't change the physics or physiology but dramatically changes the risk profile.
For perspective, all US Navy First Class Divers made dry and wet chamber runs to 285'/87M when the PPO2 limit was 2.0 instead of 1.4/1.6.
We were taught techniques to manage CO
2, in the body and the gear, which produced nearly immediate results. Narcosis symptoms didn't disappear, but improved quite noticeably by the diver and topside support crews.
The US submarine F-4 sank off Pearl Harbor Hawaii with all hands in 1915. She was in 306'/93M of water. All divers survived though efficiency was severely reduced by Nitrogen Narcosis. The F-4 salvage was the leading motivator to develop HeO2 diving in the 1920 and 30s at the
US Navy Experimental Diving Unit.
Obviously, deep air risks can be managed but it comes back to the original question, why are you making the dives? Exploring wrecks in remote locations with minimal facilities might be one reason for deep air. The cost and availability of gas might be another.
In my experience, slowly working deeper in order to learn to manage symptoms is a critical component. There is considerable debate regarding short term diver acclimatization to Narcosis. It may not be measurable by conventional cognitive tests, but higher work efficiency was consistently reflected in diver's performance on all the commercial deep air jobs I have been on.