JJ has been using 50/50 for his 70 bottle and 35/25 for his 120 bottle now for a few years. Bill Mee has been using heliox, I have been using nitrox. Bill Mee gets the cleanest results.
We have been trying to see what works best.
JJ and I played sports all our lives, I was a defensive back and JJ was a linebacker at U of Florida. That takes a toll on the knees. JJ found that when he used the 50/50, he had no symptoms of any kind in his knees, when he used nitrox, they felt weird afterwards. My knees do not react to deco at all, so I can not tell by that measure.
Bill Mee found that he was able to speed the deco severely by using all heliox. I just do the same thing over and over as the baseline, so we can see if it is the gas or the deco that is successful or unsuccessful.
The overall changing of the shape of deco and the gas choices were done by myself and JJ through trial and error, and by watching what happened with other team members.
Interestingly, even the most fit guys, like Bill Gavin, would get bent if the used 30-40 oxygen bottles for 110-120 starting depth and then the oxygen, whereas if they used 35, 50 and oxygen they did not get bent, so that is how we got there. JJ and I found that using the trimix in the deeper deco gases improved results massively. JJ and I also found that lowering the oxygen in the bottom gas and boosting the helium made deco a lot faster and cleaner, contrary to what the "theories" tell us.
In general, we found that helium is a wonder gas for solving the deco problem.