Yes. A softer o-ring will cause more friction in the piston movement at higher tank pressures.
MK10s generally have more rise in IP at high tank pressures than do other SP balanced piston 1st stages. I'm sure this is due to the smaller piston head. Basically, there is less total force on the piston head, with the same friction issues of the MK5 at the HP piston o-ring spot, so friction increase is a higher percentage of total force. The more that o-ring extrudes or gets moved around, the more friction there is and that increases the force required to push the piston against the seat. Higher duro o-rings are supposed to extrude less. You may already know this stuff, if so please excuse my verbosity.
The best performing HP o-rings I've used are 90 duro polyurethane o-rings. But they have a different set of problems, primarily shorter shelf life. I got a batch of bad ones once and I just stopped using them, now I use EPDM or viton.