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The status quo remains until proven otherwise. Its how standard scientific method and peer review works.
Otherwise i could quite happily state "I have pink fairies living at the bottom of my garden that only i can see and talk to" and pass it off as true unless you can prove otherwise.
FWIW there have been some small scale studies and all have failed to find any reduction in fatigue (however you attempt to quantify that) over a placebo. But that isn't relevant to the above. Its a very difficult thing to test and measure but there is currently no evidence supporting a reduction in fatigue nor in fact is there any postulated mechanism as to why it would that stands up to any scrutiny. However placebo effect is known to and scientifically proven to have a physical effect on a person.
Problem comparing dives done on two separate days means you cant account for variation of daily conditions, like eating, drinking, possible beginning sickness etc...
Research by Harris, et al (2003) supports the idea that the reduction fatigue experienced when using Nitrox is solely due to the reduction in subclinical DCS rather than any inherent property of Nitrox. In their double blinded, randomized controlled study 11 divers breathed either air or EAN36 during an 18m dry chamber dive for a bottom time of 40 minutes. Two periods of exercise were performed during the dive. Divers were assessed before and after each dive using a range of performance measuring tests. Diving to 18m produced no measurable difference in fatigue, attention levels or ability to concentrate following dives using either breathing gas. As a result of this and other research the current thinking at this time is that there is no difference in terms of fatigue between diving air and Nitrox."
I don't think so. It wouldn't hurt, but with hits being so rare - DAN does not support Nitrox use for safety margins. It's most beneficial on deeper, square bottom profiles like many wreck dives, but the Nx divers generally just stay down longer and surface with similar computer readings as the Air divers who surface earlier - which negates any safety ideas as well as sub-clinical DCS relieve.Would it be correct to say that using Nitrox would increase your margin of safety if you used it on the last day of diving before flying? If so, this by itself would be a pretty good justification for its use...