Latex seals are thin and flexible and, in my experience, easier to get in and out of. They're also fragile and, on me, don't last very long. Neoprene seals are bulkier and a little harder to get into and get straightened out, but they have intrinsic insulating capability, so they are warmer. They are less fragile, and can be repaired if they are damaged. They last longer. A lot of people say they tend to leak a little bit, but that hasn't been my experience with the other suit that I had changed over.