Adjustment on the MK11 is completely isolated from the seat.
All it does is adjust the external spring pressure on the TIS spring disc (which, with the spring washer, act as rotation isolation) and then through the diaphragm, diaphragm disc and pin to the poppet where the seat is.
View attachment 843481
You can adjust "hot" and purge the 2nd stage to check the new settled IP. Mk17, Mk19 should be the same.
For 2nd stages - depress the lever for orifice adjustments (which practically means depressurizing.)