First, regarding cuff dump versus shoulder dump, I found the cuff dump very irritating, because it often dumped gas when I needed to do something with my left hand. It is easier to keep the shoulder down and prevent unintentional dumping from a shoulder vent. Cuff dumps come in two types, and one is not variable. I have heard that those tend to get clogged with debris and leak. I do not know this from personal experience.
A properly located shoulder dump valve is very easy to use, and requires only a slight roll of the body or an extension of the shoulder to vent. I can do it while using a scooter AND keeping my light out in front of me. However, if the valve is poorly sited, it can be a major PITA to get gas out of the suit. You do NOT want the valve on the front of the arm, or on the chest!
I have used both neoprene and latex seals. Neoprene wrist seals have the disadvantage that most dry glove systems will not work with them. Neoprene neck seals have many advantages -- they are softer, warmer, and can be repaired. They do tend to leak a bit more, and they do stretch over time (but can be wedged out and resized at least once as they do). I was warned that they don't work as well for women, because the ratio of our head diameter to neck diameter is much greater than for men, and it proved to be true. A seal small enough not to leak was extremely difficult to get over my head; once it was easy to get on, it leaked like a sieve. I'm back with latex now.