If everything fits well you are pretty comfy overall. Tips I've learned along the way include:
1. Suspenders are you best friend to avoid the crotch hanging down too far and impeding your leg movement.
if you don't have suspenders you need to hike the legs up at your thighs as you enter the water or you end up with the crotch of the drysuit hanging down several inches too low and it makes kicking a bit cumbersome.
2. The base layer needs to be well fitted. If it's too big or small it can restrict your movement once you get the DS on. Wadded up baselayer is not comfy.
3. take your time when gearing up and make sure seams lay properly, your DS is not bunching or binding, and everything fits the way you like it. If it doesn't fit the way you want it to on the surface you won't be happy under the water and nothing sucks more than hating how the clothes fit you at minute 72 of the dive knowing you have 20 more minutes to go before you can strip it all off.
4. layers of clothing under a DS is fine, so long as you layer them properly. Don't put 2 fuzzy things together or the friction of the 2 fuzzy layers will mean your clothes will bind and bunch. if you have fuzzy expedition weight long-johns, get the kind with smooth/slick outsides so that they slide against the fuzzy mid-layer.
5. Don't always believe men when they say they are warm and you should wear what they do.
Women's skin vaso-constricts sooner and more aggressively than men, which means that our skin is colder to the touch than men. That colder surface temp means that we don't radiate heat like men which is then absorbed/reflected back by the clothes we wear. I was told that the 400g thinsulate suit by DUI and the Merino Pinnacle layer were overkill and I wouldn't need such a thing diving in the PNW. So I spent almost 2 years freezing my @$$ off, miserable, buying 300$ layer after layer hoping to find the right combination. Then I read that Lynne is also cold sensitive and even has taken to wearing a heated vest lately!
6. Dry suit seals are tight, you feel like you are choking on the surface, but once in the water the discomfort disappears almost like magic. If it's still tight under water, the seal needs to be stretched or cut down. I still hate that part, but know it will get better once we submerge.
7. Front zip suits are great, but due to their design they are inherently more bulky in the torso than a back zip. There are more panels, more fabric, more seams. That means fit is even more important, and if you have a big baselayer on, and are blessed in the chest area, you can start to feel a bit like a turducken on Thanksgiving day. if you don't like the bulk you should consider a back zip.
