The night before is the only way to take Dramamine. I get sick in seas of 4-6 or better, and in 10 footers (when the boat is hooked) I am worthless. If I know I am going to get pounded, I start the night before, 50 mg. My crew know to get out of my way if I am not properly medicated, because I am jumping out and making a negative entry to get out of the surf. I rarely get sick, though, because who wants to be out in those seas anyway.