Probably not the best practice.
??? Screws in a drysuit inflator? I think we need minimum a brand name here, better yet a picture. Never seen a suit inflator with screws in it, and I've seen a bunch. Well, under the button in the SiTech there is a small screw, actually more of a bolt with a hex head. It's part of the way it's assembled. But tightening that (reasonably) does not affect the function.
Note - when you unplug the hose, then plug it back in and inflate you are likely sending new saltwater into the valve. Not hooking up, fixing this on descent, and doing this is a common source of contamination.