biscuit7:
I
A side note, I didn't want to bring it up really, but here goes... Chimps have 48 chromosomes to a humans 46 and share 98% of our DNA. Donkeys and horses have 62 and 64 chromosomes respectively and share less common DNA (the number escapes me at the moment) and can produce offspring. An experiment that will never take place but has crossed plenty of minds would be to see if chimps and humans can hybridize and the commonly accepted theoretical answer is yes. It would be ethically unsound to try it, but my money is on the probability it would work.
R
It's a little more complicated then that.
In order to be able to reproduce you need for the chromosomes from each parent to be able to pair up (pairing is based on the DNA sequence). If chromosomes can pair up, chances are you can make offspring. If chromosomes cannot pair up cells cannot successfully divide, and as such you cannot produce offspring.
In the case of donkey and horse chromosomes the major difference is that one of the chromosomes in horses has split to form two in the donkey (I may have that backward, it may have been a fusion of two into one). But aside from that the structure of the chromosomes is pretty much the same. As such the horse and donkey chromosomes can still align, and thus you can make mules.
Humans and chimps are a different story. As you mention, there is very little difference between us and chimps within genes - there is more of a genetic difference between some breeds of dogs then there is between humans and chimps. But unlike donkeys and horses, the differences between our & chimp chromosomes is quite a bit different. Rather than having one or two chromosomes which have split or merged, it looks more like someone took a pair of scissors, randomly cut our DNA into lots of pieces, and then randomly glued them together again. As such, if you map human chromosomes onto chimp ones, you'll find that each chimp chromosome consists of 2-4 "chunks" of different human chromosomes "glued" together.
Because of this you cannot get proper alignment of the chromosomes, and thus cannot get successful reproduction. For rather obvious ethical reasons this experiment has not been done, but we have done a similar experiment which basically tells us the same thing.
What we do is take a chimp cell and a human cell, and force them to fuse together (say, 2 blood cells, or liver cells, or whatever we have on hand). If the chromosomes in that cell are capable of aligning for proper cell reproduction, you'll see that the daughter cells contain all of the original chromosomes. If the chromosomes cannot align properly you'll see that the daughter cells contain only some of the chromosomes, and you'll find fusions, deletions and translocations within the chromosomes. Often, the resulting daughter cells are cancerous; that is, if they don't just end up dieing.
Bryan