From the Nautilus "2" manual?
It is NOT A PLB. A PLB is generally defined as being a junior version of an EPIRB. The PLB usually is smaller and has half the battery life. Both transmit a 406MHz signal to the COSPAS SAR/SAT program, which monitors for distress transmissions.
The newer model Nautilus is a marine radio. While it has a standard GPS receiver in it, and it uses that to determine where it is, it does not "talk" to any satellites. Instead it uses the standard AIS DSC(marine VHF) local radios, and it broadcasts a LOCAL signal that nearby vessels should pick up.
One system is local. The other is international, with a global infrastructure.
If you are in an area that is not infested with boaters who have their VHF radios turned on, or commercial traffic who may be required to have it on, the new Nautilus will not help you. You'd need a real PLB, or an EPIRB, for that.
While most modern GPS receivers can acquire a position lock in half a minute, also be aware that they need a good sky view. If the satellites are low to the horizon and you are surrounded by mountains? Not so good, not so fast. If you have taken a plane flight, and the receiver was last turned on 1500 miles away? Eh, yeah, it will take longer because it is looking for satellites in the OLD location. So, you might want to turn it on and let it settle down after your flight. And wherever you are it doesn't REALLY get a good signal lock until it has seen the refresh signal on the GPS system, which is only passed to the satellites once every 17 minutes. So, for EPIRB and PLB, leave it on once you turn it on. For AIS systems? If you think there's no shipping in the area...maybe save it.