Suppose we were to compare two diets. Group A would be eating kale-bean sprout salad, and group B would be eating BigMac. If we asked people to assess whether kale or burger make them feel better, we would probably have a hard time getting a useful answer. Some people, more attuned to their body, might insist that eating kale makes them feel energetic, and clear-minded, and when they tried a burger once, it just made them feel drowsy and bloated. Others might insist that a burger makes them feel pleasantly full and calmer, whereas bean sprouts always left them hungry and unsatisfied, possibly contributing to residual anxiety. Many would be unable to tell the difference beyond the taste, others would insist they sense acutely the harmful effects of homeopathic amounts of some conservative used in the production process or the intense negative feng shui of a rectangular container that their tofu came from. The subjective experience of the kale-bean sprout vs burger diet would be as much mental, as it would be physiological...
A long-term study would demonstrate that one group has more folks who die from heart disease, and the other more folks, who suffer from ailments resulting from unbalanced diet. Then again, one group would be more likely to ride a bike to work every morning, others would spend evenings marinating their livers in front of the TV, while following the next episode of the Kardashians. Generations of nutrition scientists would be scratching their heads, trying to wiggle their way through the maze of conflicting factors while wrangling massive 80-dimensional spreadsheets sparsely populated with unreliable data from a handful of surveys.
FWIW, my wife's brief experience with Nitrox was overwhelmingly negative... she's convinced that Nitrox causes her headaches.