The Iceni
Medical Moderator
Fresh water drowning;- all caused by osmosis.
Instead of air, low osmotic pressure fresh water finds its way into the alveoli. Since the osmotic pressure of water is infinitely less than that of the plasma there is a mass transfer of water from the alveoli into the pulmonary vascular bed. This, of course dilutes the arterial blood.
This subsequently results in mass transfer of fluid from the (diluted) plasma into all muscle and connective tissue cells and interstitium, resulting in swelling of these cell types; seen as oedema.
One of the affected cell types is the erythrocytes, which swell and burst due to the stretching of their cell walls to accomodate the greatly increased volume within the cells; haemolysis. This releases haemoglobin molecules into simple solution. Anaemia and asphyxia results . In addition these molecules clog the filter mechanism in the glomerulus of the kidneys; which are no longer able to function.
Waterlogging of the lungs can be relatively easily reversed and the lungs often recover (dry lungs).
Cerebral odoema also occurs with the risk of brain damage and fatal "coning".
Compare this with salt water drowning.
Sea water is about three times the concentration of plasma. Thus the osmotic pressure is the reverse of that seen in fresh water. This has two effects. Fistly if even a small ammount of sea water reaches the alveoli they become filled with a blood-stained foam, from the plasma, which "smothers" gaseous exchange.
Secondly, high osmotic pressure salt water causes the denaturing of surfactant which is required to keep the lungs inflated. The lungs deflate and acute lung injury results (formally known as adult respiratory distress syndrome). The is very difficult to treat and death is due to asphyxia.
Before the dive my renal function was fine, as it is now. I agree that electrolyte disturbance is a feature of chronic renal failure and potassium concentrations, in particular, can be associated with cardiac arrythmias and LOC but not in my case!
I have written this from memory, so it may be incomplete. However, as I understand it the treatment of fresh water near drowning is more successful than salt-water near-drowning.
Regards,
Instead of air, low osmotic pressure fresh water finds its way into the alveoli. Since the osmotic pressure of water is infinitely less than that of the plasma there is a mass transfer of water from the alveoli into the pulmonary vascular bed. This, of course dilutes the arterial blood.
This subsequently results in mass transfer of fluid from the (diluted) plasma into all muscle and connective tissue cells and interstitium, resulting in swelling of these cell types; seen as oedema.
One of the affected cell types is the erythrocytes, which swell and burst due to the stretching of their cell walls to accomodate the greatly increased volume within the cells; haemolysis. This releases haemoglobin molecules into simple solution. Anaemia and asphyxia results . In addition these molecules clog the filter mechanism in the glomerulus of the kidneys; which are no longer able to function.
Waterlogging of the lungs can be relatively easily reversed and the lungs often recover (dry lungs).
Cerebral odoema also occurs with the risk of brain damage and fatal "coning".
Compare this with salt water drowning.
Sea water is about three times the concentration of plasma. Thus the osmotic pressure is the reverse of that seen in fresh water. This has two effects. Fistly if even a small ammount of sea water reaches the alveoli they become filled with a blood-stained foam, from the plasma, which "smothers" gaseous exchange.
Secondly, high osmotic pressure salt water causes the denaturing of surfactant which is required to keep the lungs inflated. The lungs deflate and acute lung injury results (formally known as adult respiratory distress syndrome). The is very difficult to treat and death is due to asphyxia.
Before the dive my renal function was fine, as it is now. I agree that electrolyte disturbance is a feature of chronic renal failure and potassium concentrations, in particular, can be associated with cardiac arrythmias and LOC but not in my case!
I have written this from memory, so it may be incomplete. However, as I understand it the treatment of fresh water near drowning is more successful than salt-water near-drowning.
Regards,