For consistency and ease of measurement, I like to find the amount of lead needed to be neutral at the end of a normal exhale. This is easy to hit repeatedly, unlike the vague "lungs half full" or similar guidance. For the actual lead needed, just increase that amount by the weight of the gas less 1 lb. (If you have to breath that last lb of air in an emergency, you can remain neutral with a slightly larger exhale.)
To convert psi of air to lbs of lead to find that adjustment, divide the pressure by 379 (LP95) or 512 (AL80). For instance, if you are neutral with an AL80 with 2000 psi, the increase would be 2000/512 - 1 ~= 3 lb to add to whatever lead that made you neutral. This way, there is no need to drain the tank down to reserve pressure.