the force require to shear a scuba valve is such that if a crash is sufficent to do it, you're already in a world of hurt. block/chock the tanks so they aren't likely to roll around, and don't worry about valves getting knocked off.
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Knavey:My buddy and I had a disagreement on the last trip on how the tanks should be positioned in a vehicle when you are transporting them. Unless you transport them upright, there are only 5 possible ways that I can see. The theory is that if for some reason (like a wreck) the valve separates from the tank...something is going to cause damage. The tank moving, or the valve flying off. Which position is going to be best if that happens?