I've used both, extensively, and frankly I believe that what to have for breakfast is a far more important decision than a single tank rig with or without an STA.
If you're using an STA, the tank is ever-so-slightly further from your backplate. Like half an inch. I can't tell the difference, tell me you can? The tank also sits up nice and straight without any extra effort, thats cool, but not an absolute requirement.
If you're not using an STA, the tank sits ever-so-slightly closer to your backplate. If you only have a single anti-roll insert in the middle of your wing, you'll just need to cinch down the bottom cam band, nudge top of the backplate one way or the other so the valve is centered over the middle of the plate, and then cinch down the top cam band to make sure its relatively straight.
After running to the fill station, packing my gear, loading the truck, making a sandwich, packing some drinks and snacks, driving to dive site, unloading the gear, donning my drysuit, donning my gear, waiting for the guy who is late, teasing the guy who is late, having a great first dive, doing a surface interval, having some lunch, hanging out with the guys, thinking about how glad I am to be diving and not home painting the garage, changing the tank, going for another dive, seeing some cool ****, nailing a perfect ascent but getting lost and teasing the guy who was supposed to be navigating.... in all of that, taking 20 seconds before splashing to check tank orientation a tad because this backplate doesn't have an STA, I'm not really feeling put out or inefficient.
Either way, no rocket surgery involved.