It depends what you have the R190 on.
If the first stage is unbalanced (a Mk 2) the IP will drop about 20 psi from a tank pressure opf 3300 psi to 300 psi. In that case, you want the IP at or very close to 145 psi at 3300 psi tank pressure to ensurer it is still a healthy 125 psi at low tank pressure.
Another issue with an unbalanced first and second stage combination is that you want to adjust the second stage for minmum inhalation effort at the highest IP it will encounter. If you adjust it to a low inhalation effort at a low or midrange tank pressue, it will freeflow slightly at high tank pressures.
If the first stage is balanced the IP will be stable. How stable depends on the design. The older Mk 5 and MK 10 would vary about 4-6 psi while the Mk 20, MK 27, Mk 17, etc, will not vary at all. In that case, you can adjust the second stage inhalation effort at any supply pressure and not worry about it.
On some piston first stages (like the Mk 2, Mk 3, Mk 5, Mk 10, Mk 15, Mk 20) IP adjustment is done in 5 psi steps with shims so adjustment from 145 to 143 psi is not really possible (or really needed either). On a diaphragm design with a sporing adjustment pad or with the Mk 25 with the adjustable seat retainer, precise IP adjustment can be achieved. But again a less than 5 psi change in IP makes no difference in how a first stage performs, what matters is the second stage adjustment.
On the R190. the inhalation effort is primarily adjusted by turing the orifice in or out slightly, although in some cases, it may be neccesary to readjust the nut securing the lever on the poppet assembly. In a few cases, it may require a new spring if the old one is too stiff to get the inhalation effort down to the minimum spec.
The biggest potential problem with a dual adjustment second stage like the R190 can occur when increasing the inhalation effort. As the orifice is turned in to increase inhaltion effort, it increases the play in the lever, if the play in the lever is excessive, the dipahragm can no longer fully open the valve and a greatly reduced air delivery will result from the restricted working range of the valve. If the lever is properly adjusted, the reg should begin delivering air with only a slight depression of the purge button. If it requires more depression than normal to get the reg to purge, it should be taken in to be readjusted.