One of the points I find again and again is that these folk are incredibly fit individuals, and so far those that recognize and thumb appropriately are the survivors.
For IPE cases observed in surface swimmers, there may be an element of exercise physiology/adaptation in fit individuals that increases IPE susceptibility.
(Something to keep in mind is that scuba divers are subjected to increased ambient pressure [compared to surface swimmers], so it's possible that development of IPE occurs in a slightly different way.)
On the other hand, the people logging the most time in the water while exercising at the surface are probably folks who are in fairly good shape.
The point I'm trying to make here is that even if there is a correlation between IPE susceptibility and fit individuals, it could just be a coincidence.
FWIW, I don't think our tracking of IPE cases has been very good thus far. We can all probably agree that more data needs to be collected about scuba divers, swimmers, and triathletes in which this condition is occurring.
Pulmonary edema, in general, can have many different causes. Heart and respiratory physiology is involved, but other factors can give rise to fluid accumulation in the lungs. For example, there are certain prescription medications which can induce the condition. It would be important to identify such "explainable" causes in the population of scuba divers with a history of IPE.
If you remove water from the equation, you can find case reports of athletes suffering from pulmonary edema during strenuous exertion (ultramarathoners [
McKechnie et al., 1979], ultracyclists [
Luks et al., 2007). There have even been reports of people suffering from pulmonary edema due to emotional stress, sexual intercourse, and exertion in a cold environment (
Wilmshurst, 2004). Interestingly, there are physiologists on either side of the fence, saying that pulmonary edema can/cannot occur in human athletes performing strenuous exercise at sea-level (
Hopkins, 2009;
Sheel and McKenzie, 2009).
Here at UCSD (where we have a pretty strong respiratory physiology research effort), Sue Hopkins has done some interesting work on exercise physiology that may be relevant to IPE. You might want to do a Pubmed search for her work. A few years ago, I know that her lab was investigating the mechanism of high altitude pulmonary edema (HAPE), which has been hypothesized to have a similar pathophysiology to IPE. One of my friends did her Ph.D. in that lab, and she was always bugging me to be a subject for one of her studies on altitude sickness. I was never sold on being a guinea pig for a few weeks in the summer at the White Mountain Research Station. Sounded a little isolated to me.