Yes, it can be done.
Take, for example, a multi-level dive to 100 feet in which the diver goes to that depth (taking 2 minutes) to look at some garden eels, stays 3 minutes, ascends to 60 feet, stays there for 25 minutes, ascends to 30 feet, stays there for 35 minutes, and does an ascent with a 3 minute safety stop. That is a nice dive with a total dive time of 69 minutes.
The diver could have done the same multi-level dive with the PADI tables. Of course, some of the times would need to be changed, because the maximum bottom time is 20 minutes. That means the total dive time, assuming the final ascent and safety stop from 30 feet, would be 24 minutes. So, yes, it can be done. No real difference, right?
On the other hand, if you are following a dive guide in a place like Cozumel, you can't use tables, because the multi-level dive you do with them will violate the table NDL about half way through the dive.