Rhone, I actually see the opposite, generally on longer/deeper dives my tissue loading at the end is much lower than when I'm doing NDL diving because I'll do an extra few minutes on my O2 stop and it lowers the N2 loading considerably. That being said, I'm not going to base anything off of what the cabin pressures say they're going to be. I base it all off of 0.5ata/16000ft just to be safe. Having worked with DAN quite a bit on the FAD, I have a bit more liberal times for myself than the agencies do, but I've also done working dives in the chambers then been flown, so I have a bit more real world experience in controlled environments.
fwiw, I'm ok with 6 hours if I do an extended deco stop, but typically it is more like 8-12 since I tend to take morning or late night flights.