I'm lefty. So, grabbing the Octo and ripping off my left chest D-ring would come easy. My right hand is usually busy with holding on my underwater camera.
Anyway, this weekend I'll be practicing this with my dive buddy. I have never done it in 15 years of diving. So, it's about time to do it. My dive buddy has the normal configuration of both his 2nd stage reg & Octo coming out of the right side of his 1st stage. We'll see the difference.
If you buddy's secondary routed on the right shoulder has a properly-long hose, it will work OK for you, even if coming "the wrong way" for you, as there will be hose enough for the S-turn.
My experience had been of problems when donating a primary, which in normal rec configuration always has a short hose... Of course, in DIR configuration, the primary has a very long hose, so again there is no problem.
Problems arise when "mixed" configurations are used, or when people is not expecting an unusual configuration.
I see that in a trained group of DIR divers, where everyone is equipped and expects for a primary donate with a very long hose, there are no problems at all (COVID restrictions apart).
Personally I think that there are three safe ways of donating a reg:
1) the DIR way, primary donating with a very long hose, and a necklaced secondary with short hose, but usable only if all the divers are properly equipped and DIR-trained, and if COVID restrictions are removed.
2) the standard PADI way: primary with short hose and possibly necklaced, NEVER to be donated, and a secondary on the right shoulder with a long yellow hose (long enough for being donated properly upside, thanks to an S-curve on the hose); this works both as an AAS for the owner and as a reg to be donated.
3) the method developed by me and my wife in the eighties, requiring a tank with double valve and post, carrying a third complete reg (first and second stage) on the left post, routed on the left shoulder, with a long yellow hose: this reg is designated to be donated only (not to be used by the owner).
I understand that 3) is much less common than the other two, and requires the availability of tanks of proper size (at least 15 liters at 232 bars) and with a double valve and post. These tanks are the standard ones here in Italy, or in tropical resorts with Italian dive centers, but it appears that they are uncommon in other places, making the third approach unfeasible.