Side-mounting would eliminate the inconvenience of reaching back.The price you must pay includes the inconvenience of periodically reaching back to open and reclose the isolation valve to equalize cylinders, greater hassle breaking them back down to singles, and introducing two potential failure points on the valve (where the plug or isolation valve install) compared to a dedicated K-Valve. Both methods allow using the second cylinder as a hard reserve… sort of a higher volume and much more reliable J-Valve.
BTW, I am not side-mounted trained.
Given choice, i would prefer a twin set with manifold than a single.