Bubbletrubble
Contributor
@denisegg: Thanks for the link. I'm glad that some researchers are looking at changes in pulmonary artery pressure during diving. It's interesting that the investigators in the linked study are using 50mg of sildenafil (Viagra) as a pharmacologic intervention. Phosphodiesterase-5 (PDE5), the enzyme inhibited by sildenafil, appears to be expressed only in the arterial smooth muscle wall of the lungs and the penis. Nitric oxide (NO) is involved in the PDE5 pathway. NO activates guanylate cyclase which generates cyclic GMP, causing vasodilation (relaxation) of the smooth muscle walls. Presumably, this vasodilation can prevent/reverse pulmonary artery hypertension. Interestingly, I read somewhere that some physicians were treating high-altitude pulmonary edema with sildenafil.This is the link to the study but there are no published results:
Immersion Pulmonary Edema - Full Text View - ClinicalTrials.gov
I'd love to hear the reactions from some of the study participants.
After reading your last post, it sounds to me like pulmonary specialist #2 has a great attitude -- promising to research IPE, formulate a plan, and discuss it with you at your next appointment. That's exactly the kind of specialist I'd want. Sorry to hear about the run-around you're getting with the medical record releases. That's the nature of sharing medical info nowadays, I'm afraid.
Take care.
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