Another thing to consider is how many incidents have occurred that are attributable in some way to the presence of the isolator that would not have occurred in the absence of the isolator. For example, how many people have discovered an isolator that was closed at some point when it shouldn't have been?
There have been at least two fatalities that I am aware of that may possibly have been prevented if the isolator was opened. Both of those should have been caught in a pre-dive check, and at least one of those should have been caught during the dive when the pressure gauge wasn't dropping.