This is incorrect if you actually mean "available" rather than "active". (Various posters above have conflated those two terms.) There is zero issue having various gases defined & available (i.e., ON in the gas menu) on an NDL dive, and it is quicker to select your single gas from the pre-defined choices. Also, NDL is based on the *active* gas, and all others are ignored until NDL is exhausted. As far as I can tell, the OP is doing NDL dives on a LOB.leaving 18/45 or 99 activated for a recreational profile (!) will dork up the computations.
While I don't think it applies to the OP, even when mandatory deco stops kick in, ceilings/stop depths are computed with the active gas. Follow those and your profile will be identical to one where the actual gas is the only one defined or whose status is set to ON.