agree with Prostar - if you manage to shear a valve off whilst you're driving, you've just had a major collision and probably won't be in a position to worry about exploding tanks. You probably won't be in much of a position to worry about anything at all, actually.
The easiest and most convenient way is to load the tanks horizontally with the valve pointing to the rear of the vehicle - this just makes it easier to get the things in or out.
Remember that a tank can withstand 3000psi of pressure every time it's filled - a few knocks are not going to cause them to explode. If they did, I would be long dead by now and pretty much every boat I've ever worked on would have sunk.
Load them securely, drive carefully, and don't worry about it.
Cheers
C.
I don't think that's the best choice of reasoning Crowely.
Convenience and safety don't always go hand in hand.
It's very unlikely for a tank valve to shear off, but in the unlikely case that it does, you now have a 20lbs rocket with 3000psi of thrust behind it aimed right at you.
A bit more if you use HP tanks.
So if you were in an accident and had a tank shear, then yes, in fact you WOULD be in a position to worry about exploding/rocketing tanks. Air bags don't do much good for secondary impacts.
Not even suprise bu****x jokes can make up for a situation like that

Better to position tanks sideways or with the valve pointing towards the passengers.