If you loop a zip tie through the hole, there should be no problem opening it, even with gloves on, for you can pull on the zip tie loop. A lanyard slipped over the wrist solves the problem of dropping the knife.
The problem I see is closing the knife while wearing neoprene gloves. The lock style on the Atlantic Salt is a lockback with a David Boye dent. The "dent" makes it harder to close the knife accidentally, but with gloves on, I could see it being hard to depress lockbar.
The advantage of a fixed blade is that it has a sheath always at the ready. With a folding knife, the handles are the sheath, and unless you can close the knife, you don't have a sheath.