They can kill you plenty fast, I consider minutes to be "fast"
Brian Bugge died in Hawaii a couple months ago in a couple minutes (on the surface with his O2 off)
The surface has always been an area of high risk on CCR.
There does seem to be a recurring issue of CO2, which is often put down to working hard on the surface, swimming against current , failure to pre-breath, etc. Similarly low PO2 problems due to failure to turn the unit on or the O2.
What often puzzles me is how you can miss a low PO2 alarm. Granted, a hypoxic dil can be a contributing issue. However, the scream buzzer and red flashing light should give you a good idea you have an issue (at least on my unit). However, I have dived with the odd person who struggle to hear the alarm, and who's eyesight leave a lot to be desired.
I must admit I find the newer colour handset a major improvement with respect to readability compared with the old monochrome display I had.
With most people I've found them disciplined when it comes to unit assembly and initial post assembly checks.
It is often the rush for the second dive where people are less disciplined, and I have to accept that I have fallen into this trap as well. This is where I, and others have entered the water with the O2 off, having turned it off after the first dive. There is significant risk if you stay on the surface or are working hard and don't rectify this. If you are descending, the PO2 is rising, so you have more time. It shouldn't happen, but it does.
The fact that more units now come with a BOV as standard is a major improvement. But you do need to remember if they are plumbed into the onboard DIL you have very little gas on OC.
During a dive I have often found that I 'zone out' the steady green HUD, but as soon as it starts to flash, or I get a red I become very aware very quickly.
The other area of risk is ascent, when the PO2 is dropping.
(Descent has rising PO2, which has its own issues.)
Like many, I have fallen into the trap of allowing task loading to distract me from the unit itself. Having been made aware of my failure by a change on the HUD, well before the alarm has gone off. Carrying a camera adds to the risk of task loading. But it has normally been contributing factors on the dive, poor vis, navigation, buddy monitoring etc. Like it's often said, it's easy to dive (OC or CC) when conditions are good, the difficulty comes when the conditions are bad, or things start to go wrong.
Gareth