The TX100's make hose routing nicer for doubles, but as far as breathability, I couldn't tell the difference at depth when both were set at the same IP. I got rid of my TX100 for an ATX50/DS4. There is talk from Apeks that they may discontinue the 1/2" port nonsense. If they do that, I'll probably get a couple 100 first stages.
I haven't even seen an ATX200. It seems kinda gimmicky to me. I just don't need a light weight first stage, and the breathability difference is likely insignificant. Perhaps a machine could tell the difference. One thing is for certain, you'll pay out the nose for a 200. The ATX50 second stage is nearly identical to the ATX200 second stage other than the size of the heat exhanger. The same can be said about the TX50 and TX100's second stages.
IMO, the best reg combo on the market (for the money) is the TX50/DS4. It's just a bullet proof reg combo with an awesome track record within the tech community in a variety of conditions. You won't beat that combo for the money. In fact, you'd be hard pressed to beat that combo with any money. However, I really like my new ATX50 second stage too. You can get the ATX50/DS4 from Simply Scuba for $280 or something. I would recommend that combo too. The lightweight second stage is luxury that, if you can afford it, is pretty nice.
Take care,
Mike